在第一发精神分裂症中,同位素连接性和临床症状之间的关联
Hengyu Zhang1, Qijie Kuang1, Ruikeng Li1
1Department of Psychiatry, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, 510370, China.
Heliyon
|May 6, 2024
概括
第一发精神分裂症 (FES) 患者表现出大脑功能连接的改变,特别是在近中心叶片,丘脑和上回形中. 这种减少的连接性与负面症状相关,并且可能独立于白质变化.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 在精神分裂症中注意到异常的大脑功能连接 (FC).
- 有限且不一致的研究存在于精神分裂症的同位素脑区之间的FC.
- 这项研究调查了第一发精神分裂症 (FES) 的同位素连接性.
研究的目的:
- 为了比较FES患者和健康对照者 (HC) 之间的同位素连接性.
- 评估改变的同位素连接性和FES的临床症状之间的相关性.
- 探索功能性和结构性大脑变化之间的关系.
主要方法:
- 静止状态功能磁共振成像 (rs-fMRI) 使用voxel镜同位素连接 (VMHC).
- 包括31名FES患者和33名HC患者.
- 使用5因素正负综合征量表 (PANSS) 的定量症状评估.
- 部分相关性分析,以链接连接和症状.
主要成果:
- 与HC相比,FES患者在近中心叶区 (PL),丘脑和上回形 (STG) 中的VMHC降低.
- 在相关的大脑区域,没有发现白质体积 (WMV) 的显著差异.
- 双边STG中的VMHC与负症状正相关;右丘脑的VMHC与无组织/具体症状负相关.
结论:
- 在FES患者的休息状态大脑中,同位素连接性发生变化.
- 变化的连接性与负面症状的严重程度相关.
- 这些功能变化似乎独立于白质结构变化,支持精神分裂症异常连接假说.
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