术内注射硫酸输液对整形手术的影响:一项前性和随机对照试验
Xiaoxiao Hua1,2, Yanling Chen1, Zhi Wu1
1Department of Anesthesiology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University, 74 Zhongshan Rd 2, Guangzhou, 510080, China.
Heliyon
|May 6, 2024
概括
术内硫酸减少了雷米芬坦尼尔的使用,并缓解了形手术患者的术后疼痛和恶心. 这项研究强调了硫酸的含量.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 手术研究的研究.
背景情况:
- 整形手术需要仔细的麻醉管理,以控制疼痛和恶心.
- 硫酸因其潜在的 analgesic 和 antiemetic 特性在手术环境中被探索.
研究的目的:
- 评估手术内注射硫酸对雷米芬坦尼尔消耗,术后疼痛,恶心和吐 (PONV),以及骨干手术患者的炎症标志物的影响.
主要方法:
- 这是一项随机对照试验,涉及75名接受正统手术的成年患者.
- 患者接受了硫酸 (50 mg/kg玻尿酸,15 mg/kg/h输液) 或盐溶液安慰剂.
- 结果包括雷米芬坦尼尔消费,疼痛评分 (VNRS),PONV发病率和血清细胞因子水平.
主要成果:
- 硫酸组的摄入量显著降低了雷米芬的摄入量 (P=0.003).
- 在硫酸组观察到,手术后严重恶心和吐 (PONV) 的发生率减少 (P=0.040) 和手术后疼痛得分较低 (P=0.013).
- 两组之间没有发现血液动力学变化或炎症性细胞因子水平的显著差异.
结论:
- 在手术内给予硫酸,有效地减少了在整形外科手术中对remifentanil的需求.
- 硫酸可以缓解早期的术后疼痛和经过整形手术后的PONV.
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