囊性纤维化肺移植中的代谢并发症 - 一项病例对照研究
Grace Y Lam1,2, Hima Patel1, Heather Sharpe1
1Division of Pulmonary Medicine, Department of Medicine, University of Alberta and Alberta Health Services, Edmonton, Alberta, Canada.
Heliyon
|May 6, 2024
概括
患有囊性纤维化 (CF) 的患者在肺移植后患上新发糖尿病的风险显著增加. 在CF患者和非CF患者之间,代谢并发症的发生率相似,这强调了CF患者需要密切监测的必要性.
科学领域:
- 移植免疫学 移植免疫学
- 肺部医学 肺部医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 肺移植后的代谢并发症尚未得到充分了解.
- 患有囊性纤维化 (pwCF) 和没有囊性纤维化 (pwoCF) 患者的移植后结果的差异尚不清楚.
研究的目的:
- 为了比较pwCF和 pwoCF之间的肺移植后结果.
- 为了研究存活率和糖尿病,血脂不良,高血压和功能障碍的发生率的差异.
主要方法:
- 在90 pwCF和90 pwoCF的回顾性病例控制研究 (2004-2017) 中.
- 根据年龄,性别和移植年份进行匹配.
- 分析包括人口,代谢和药物数据;生存分析使用卡普兰-梅尔和日志等级测试;后勤回归确定了独立的风险因素.
主要成果:
- PwCF年轻,体重指数较低,移植前ECMO使用较少.
- 在pwCF和 pwoCF之间,整体存活率没有显著差异.
- CF状态与移植后新发糖尿病风险显著增加有关 (aOR 28.7).
结论:
- 在肺移植后,PwCF面临的新发糖尿病的调整风险要高得多.
- 除此之外,pwCF和 pwoCF之间的代谢并发症率是相似的.
- 严格监测代谢并发症对于pwCF后肺移植至关重要.
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