对于急性胰腺炎的HFLC%和IG%的诊断实用性-A回顾性病例对照研究
Lin Xiao-Yan1, Li Xiao-Ling2, Zhang Le-Xin3
1Clinical Laboratory Center of Zhongshan Hospital Xiamen University, Xiamen 361004, China.
Heliyon
|May 6, 2024
概括
超光淋巴细胞百分比 (HFLC%) 和不成熟的粒细胞百分比 (IG%) 可以预测急性胰腺炎 (AP) 的进展. HFLC%,IG%,C反应蛋白 (CRP) 和白细胞 (WBC) 的组合为AP结果提供了最佳的预测准确性.
科学领域:
- 血液学 血液学 血液学
- 临床化学 临床化学
- 临界护理医学 临界护理医学
背景情况:
- 急性胰腺炎 (AP) 是一个重要的胃肠道紧急情况.
- 早期识别AP的严重程度和预后对于患者管理至关重要.
- 需要新的实验室标记物来改善AP结果预测.
研究的目的:
- 在急性胰腺炎 (AP) 中评估超光淋巴细胞百分比 (HFLC%) 和不成熟粒细胞百分比 (IG%) 的预后值.
- 评估这些标记物的预测能力,以及C-反应蛋白 (CRP) 和白细胞 (WBC),对AP进展和结果.
主要方法:
- 从623名AP患者的实验室数据的回顾性分析.
- 从第1天到第14天监测HFLC%,IG%,WBC,CRP,血清氨酶和脂酶.
- 分类为轻度急性胰腺炎 (MAP) 和非轻度急性胰腺炎 (非MAP) 组.
主要成果:
- 与MAP患者相比,非MAP患者的WBC,IG%和CRP水平较高.
- 在非MAP患者中,HFLC%在第7天显著增加.
- 结合HFLC%,IG%,CRP和WBC显示在预测AP进展方面具有很高的准确性 (AUC=0.912).
- 在第7天低HFLC% (<2.9%) 与感染,SIRS,更高的APACHII等级和ICU入院有关.
结论:
- HFLC%是AP预后的一个有前途的独立实验室标志物.
- 将HFLC%与IG%,CRP和WBC结合起来,可以提高对AP疾病发展和患者结果的评估.
- 对HFLC%,IG%,CRP和WBC的特定值可以表明潜在的AP恶化.
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