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在患有家族性腺瘤多重症的患者中,双管切除术后的结果
Arthur S Aelvoet1,2,3, Isabel Martin4,5, James Cockburn4
1Department of Gastroenterology and Hepatology, Amsterdam UMC, Amsterdam, the Netherlands.
Endoscopy international open
|May 6, 2024
概括
经过双胞胎切除术的家族腺瘤多重症 (FAP) 患者面临患上阴茎和胃腺瘤和癌症的重大风险. 由于癌症预后不佳,近距离内镜监测在手术后至关重要.
科学领域:
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
- 遗传学 是一个遗传学.
背景情况:
- 患有广泛的十二指甲多或癌症的家族腺瘤多症 (FAP) 患者往往需要全身二指甲切除术.
- 建议进行术后内镜监测,但结果数据有限.
研究的目的:
- 为了评估术后内镜监测结果和FAP患者在双胞胎切除术后的存活率.
- 为了比较胰腺双胞胎切除术 (PD) 和胰腺保护全双胞胎切除术 (PPTD) 之间的结果.
主要方法:
- 在两个专家中心进行PD或PPTD的FAP患者的回顾性分析.
- 收集关于术后内镜监测和生存结果的数据.
主要成果:
- 在119名患者中,有41%的患者患有阴腺瘤,PPTD后的发病率更高 (P <0.01).
- 2%的人患上了阴癌. 30%的人患有胃腺瘤,6%的人患有胃癌,通常是在腺多重症中.
- 癌症患者的存活率更差;大多数经手术后的胃/腹腔癌患者死亡.
结论:
- 在FAP患者中,双管切除术带来了胃和骨腺瘤和癌症的重大风险.
- 由于这些癌症的预后不佳,严密的术后内镜监测至关重要.
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