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同时发生的微生物群和粘素驱动 Pseudomonas aeruginosa 的多样化和病变适应

Michael J Bottery¹, Helle Krogh Johansen^2,3,4, Jon W Pitchford^5,6

¹Division of Evolution Infection and Genomics, School of Biological Sciences, University of Manchester, Manchester M13 9PL, United Kingdom.

ISME communications

|May 6, 2024

概括

其他细菌的存在,比如Stenotrophomonas maltophilia和Staphylococcus aureus,可以防止Pseudomonas aeruginosa在囊性纤维化肺部感染期间失去毒性. 环境变化,如粘素,可以改变这种效应.

科学领域:

微生物学微生物学
进化生物学进化生物学
传染性疾病传染性疾病

背景情况:

Pseudomonas aeruginosa 是囊性纤维化 (CF) 肺部感染中的关键病原体.
环境因素推动了P. aeruginosa的进化,但微生物群的作用尚不清楚.

研究的目的:

为了研究同时出现的细菌如何影响P. aeruginosa病毒性在体外的进化.
了解物理环境对这些相互作用的影响.

主要方法:

在体外实验进化被用来研究P. aeruginosa.
与Stenotrophomonas maltophilia和/或Staphylococcus aureus共同培养已经建立.
研究了粘素在改变物理环境中的作用.

主要成果:

同时出现的细菌阻止了P. aeruginosa的毒性丧失,而如果它们不存在,则会发生这种情况.
病毒性丧失与 Pseudomonas Quinolone Signal (PQS) 质量检测系统的vqsM和pqsR调节器的突变有关.
添加粘素减弱了同时出现的物种的保护作用,导致与单一种植的进化结果相似.

结论:

多微生物环境和粘膜状况极大地影响了P. aeruginosa的进化路径.
这些因素有助于P. aeruginosa的多样化和适应,使其从CF肺部的急性感染变为慢性感染.

关键词:

伪omonas aeruginosa 这种类型的病毒.黄金葡萄球菌黄金葡萄球菌斯诺蒙纳斯 (Stenotrophomonas maltophilia) 是一种有毒的动物.囊性纤维化症是什么多样化的多样化多样化的多样化一个叫做mucincin的孩子.病原体适应病原体适应多种微生物感染.

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