2002年至2019年2型和1型糖尿病患者因特定原因死亡率的趋势:一项基于丹麦人口的研究
Tinne Laurberg1, Susanne B Graversen1, Annelli Sandbæk1,2
1Steno Diabetes Center Aarhus, Aarhus University Hospital, Palle Juul-Jensens Blvd. 11, 8200, Aarhus, Denmark.
The Lancet regional health. Europe
|May 6, 2024
概括
癌症现在是丹麦2型糖尿病 (T2D) 患者的主要死亡原因. 这凸显了糖尿病护理中综合癌症预防策略的必要性,特别是对于患有糖尿病的女性.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 尽管心血管疾病预防方面取得了进展,但糖尿病人群仍存在持续的过度死亡率.
- 了解这种过度死亡率的组成部分及其性别特异性相互作用至关重要.
研究的目的:
- 调查1型 (T1D) 和2型糖尿病 (T2D) 患者过度死亡的原因.
- 分析2002-2019年丹麦糖尿病,因特定原因死亡率和性别之间的相互作用.
主要方法:
- 利用了2002-2019年的丹麦登记册,其中包括958,278例死亡.
- 应用基于Lexis的方法来计算年龄标准化死亡率 (asMRs) 和相对风险 (asMRRs).
- 分析了因特定原因的死亡率趋势,按糖尿病状况和性别分层.
主要成果:
- 癌症是T2D患者的主要死亡原因,大多数癌症类型 (9%257%) 的死亡风险较高.
- 与肥胖相关的癌症显示了最高的相对风险,特别是肝癌,胰腺癌和癌.
- 虽然T2D男性的多余死亡率稳定 (除了痴呆症),但T2D女性的多余死亡率增加 (每十年6-17%),除了心血管疾病之外,大多数原因都导致了多余死亡率.
结论:
- 癌症已成为丹麦2型糖尿病患者的首要死亡原因,需要在糖尿病管理中预防癌症.
- 针对性别的具体方法对于解决糖尿病女性持续较高的相对死亡率至关重要.
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