基于热方法的低标准阿莫西西林的非破坏性测量技术
Decho Surangsrirat1, Onsiri Srikun2, Chaksawat Sangawitayakorn2
1Digital Healthcare Platform Innovation Group, National Science and Technology Development Agency, Pathum Thani 12120, Thailand.
ACS omega
|May 6, 2024
概括
一种新的热量测量技术可以快速且负担得起地检测不合格的阿莫西西林,而无需破坏样本. 这种质量控制方法通过准确量化活性成分含量来确保患者的安全.
科学领域:
- 分析化学 分析化学
- 药品分析 药品分析
- 非破坏性测试 不破坏性测试
背景情况:
- 对阿莫西西林的质量控制对于患者的安全至关重要,需要准确确定活性成分含量.
- 传统的阿莫西西林分析方法耗时,需要熟练的人员,并且经常需要特定的试剂.
研究的目的:
- 引入一种新的,非破坏性的热量测量技术,用于确定低标准的阿莫西西林.
- 开发一种快速,低成本,准确的替代方法来量化阿莫西西林含量而不损坏样品.
主要方法:
- 用热方法进行非破坏性测量阿莫西西林含量.
- 方法验证包括评估确定系数 (R2),百分比恢复,检测极限 (LOD) 和量化极限 (LOQ).
- 实验中使用了度低于标准质量的水溶液中的阿莫西西林样本.
主要成果:
- 该方法实现了超过0.99的确定系数 (R2),百分比恢复率在98.70-103.40%之间.
- LOD和LOQ分别为28.11毫克/升和85.17毫克/升.
- 测量在不到10分钟内完成,显示出高分析效率.
结论:
- 拟议的热技术有效量化水溶液中的阿莫西西林含量,识别不符合标准的样本.
- 国际机构的独立验证证实了该技术的有效性和稳定性.
- 这项研究验证了使用热方法实现阿莫西西林快速,非破坏性质量控制的可行性.
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