在急性缺血性中风中循环的HMGB1及其与中风后认知障碍的关联
Zhenbao Liu1, Weixia Yang1, Jianxin Chen2
1Department of Neurology, Qingpu Branch of Zhongshan Hospital, Fudan University, Shanghai, China.
PeerJ
|May 6, 2024
概括
在缺血性中风的急性阶段,高水平的高流动性组盒1 (HMGB1) 蛋白质预测了中风后认知障碍 (PSCI) 的发展. 早期识别PSCI风险可以指导个性化干预.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 脑卒中研究 脑卒中研究
背景情况:
- 缺血性中风通常导致中风后认知障碍 (PSCI).
- 早期识别有PSCI风险的个体对于及时干预至关重要.
- 高流动性组第1框 (HMGB1) 与中风后炎症有关,可以作为预后指标.
研究的目的:
- 为了评估急性阶段循环HMGB1度在缺血性中风后3个月对认知功能障碍的预测值.
- 确定HMGB1是否可以作为生物标志物来识别患PSCI风险的个体.
主要方法:
- 对192名初始缺血性中风患者进行了前性纵向研究.
- 在入院后24小时内通过ELISA测量出循环中的HMGB1水平.
- 使用蒙特利尔认知评估 (MoCA) 评估3个月的认知功能;用于分析关联的多变量逻辑回归.
主要成果:
- 84名 (44%) 患者出现了PSCI.
- 与未患PSCI患者相比,患PSCI患者的HMGB1度显著增加 (8.4与4.6 ng/mL相比,p < 0.001).
- HMGB1是中风后认知功能障碍的独立预测因素,即使调整了混因素.
结论:
- 急期循环HMGB1水平与缺血性中风3个月后的认知功能障碍的发展有显著联系.
- HMGB1是一种潜在的新生物标志物,用于识别患有PSCI高风险的患者.
- 这一发现支持针对高HMGB1水平的个人制定有针对性的预防策略.
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