在怀孕36周时,孕妇的血管指数在怀孕期间,胎儿小或生长受限制
A Szczepkowska1, S Adjahou1, I Papastefanou2
1Harris Birthright Research Centre for Fetal Medicine, King's College London, London, UK.
概括
对于妊娠年龄小的怀孕 (SGA) 和胎儿生长限制 (FGR) 的怀孕显示出改变了母亲的血液动力学. 胎儿生长限制怀孕的血压高于SGA怀孕,但原因尚不清楚.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 怀孕期间的心血管生理学
背景情况:
- 怀孕并发症,如怀孕年龄小 (SGA) 新生儿和胎儿生长限制 (FGR) 可能会影响母亲的健康.
- 了解母亲的血液动力学变化对于管理这些怀孕至关重要.
研究的目的:
- 为了比较SGA或FGR怀孕中的孕产妇血管指数和血液动力学参数,与未受影响的怀孕相比.
- 为了研究SGA和FGR组之间的母体血液动力学差异.
主要方法:
- 对6413名怀孕35-37周的妇女进行前性观察性研究.
- 非侵入性测量母亲的脉冲波速度,增强指数,心脏输出,血压和心率.
- SGA以出生体重<10个百分点;FGR以出生体重<10个百分点加上异常的带/子宫动脉脉动指数 (PI) 或低胎儿中脑动脉PI.
主要成果:
- 与未受影响的怀孕相比,SGA/FGR怀孕显示了外周血管抵抗的增加和心脏输出量的减少.
- 在FGR怀孕中,心和腹血压比未受影响的怀孕更高.
- 两组之间大动脉硬度 (脉冲波速度) 或增强指数没有显著差异;FGR的血压高,心率低于SGA.
结论:
- 在SGA和FGR怀孕中,母亲的血液动力学反应发生了变化.
- 与SGA怀孕相比,FGR怀孕的中心血压较高.
- 需要进一步的研究来确定这些血液动力学差异是由于胎儿大小或病态生长.
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