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孟德尔的随机化研究对自身免疫性甲状腺疾病的影响

C Hu¹, Y-F Yu, K-K Tong

¹Department of Chinese Medicine, The Fourth Hospital of Changsha, Changsha, Hunan, China. liyaoyao@hnucm.edu.cn.

European review for medical and pharmacological sciences

|May 6, 2024

概括

补充剂不会对自身免疫性甲状腺疾病 (AITD) 产生因果影响,包括自身免疫性甲状腺炎 (AIT),自身免疫性甲状腺功能障碍 (AIH) 和格雷夫斯病 (GD). 在AITD患者中避免随意使用,除非缺乏.

科学领域:

内分泌学在内分泌学.
遗传学是一个遗传学.
营养科学营养科学

背景情况:

在自身免疫性甲状腺疾病 (AITD) 中的作用仍在争论中.
门德尔随机化 (MR) 提供了一种研究因果关系的方法.

研究的目的:

用MR测定对自身免疫性甲状腺炎 (AIT),自身免疫性甲状腺功能障碍 (AIH) 和格雷夫斯病 (GD) 的因果关系.
在AITD中提供关于补充的基于证据的建议.

主要方法:

利用来自大型全基因组关联研究 (GWAS) 的,AIT,AIH和GD的单核酸多态 (SNPs).
采用了MR方法,包括逆方差加权,MR-Egger和因果关系评估的加权中位数.
通过MR-Egger拦截和Cochran的Q测试来评估状性和异质性,并对强度进行敏感性分析.

主要成果:

核磁共振分析发现与AIT (OR 0.993),AIH (OR 1.066),或GD (OR 1.052) 之间没有显著的因果关系.
统计测试证实,没有显著的水平形和异质性.
留下一个缺席的灵敏度分析支持了研究结果的稳定性.

结论:

似乎不会对AIT,AIH或GD的风险产生因果影响.
没有确定的缺乏症的AITD患者不建议定期补充.

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