收回注意事项 收回注意事项
1None.
概括
2016-2018年间发表的四篇科学文章已被撤回,原因包括图像操纵,缺乏道德批准和数据不一致等重大问题. 这些撤回凸显了科学出版诚信的关键问题.
科学领域:
- 生物医学研究的研究.
- 药理学 药理学是指药理学的学科.
- 在瘤学瘤学.
- 神经科学是一个神经科学.
背景情况:
- 科学完整性在研究出版中至关重要.
- 同行评审和读者反在识别潜在的研究不当行为方面发挥着至关重要的作用.
- 伦理认可和数据透明度是有效科学研究的基本要求.
研究的目的:
- 宣布收回四篇具体的科学文章.
- 详细说明撤回的原因,包括图像操纵,数据不一致以及缺乏道德认可.
- 告知科学界关于这些撤回的信息,并维护出版标准.
主要方法:
- 该杂志的编辑团队调查了PubPeer.上读者提出的担忧.
- 调查包括检查数字的操纵和重复.
- 联系作者以求澄清和原始数据,但没有收到回复.
主要成果:
- "MCA-MAO对大脑出血大鼠的cAMP通路的影响" (2016) 由于数字重复和缺乏伦理认可而被撤回.
- "关于GLP-2在患有血管性痴呆症的小鼠中神经系统EPK信号转导通路中的作用的研究" (2017) 由于数字重复和缺乏伦理审批而被撤回.
- "P13K/AKT信号通路介导的MMP-9基因与肺癌之间的关系研究" (2017) 因缺乏伦理声明和原始数据而被撤回.
- "LncRNA LINC01116与miR-145在乳腺癌中调节ESR1表达方面竞争" (2018年) 因数据不一致,样本采集缺陷和缺乏伦理审批而被撤回.
结论:
- 鉴定到的问题影响了发表的研究的有效性.
- 总编辑和出版商决定撤回这些文章,以保持科学完整性.
- 作者缺乏回应和合作进一步支持撤回决定.
相关概念视频
Clot Retraction and Fibrinolysis
5.6K
After a fibrin clot is formed, the next step is clot retraction, a vital process facilitated by platelet contractile proteins, such as actin and myosin. These proteins pull the fibrin strands closer together and condense the clot. This action reduces the size of the clot, creating a smaller, denser structure that effectively seals off the damaged vessel. Clot retraction consolidates the clot and helps with wound healing by bringing the edges of the damaged blood vessel closer together.
5.6K
Skeletal Muscle Relaxants: Adverse Effects
358
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
358
Reticular Dermis
2.5K
The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
2.5K
Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
Spare Receptors
3.5K
Some receptors remain unoccupied even when an agonist produces a maximal response. Such empty ones are called spare receptors. In presence of spare receptors the maximum effect of an agonist drug is achieved with fewer than 100% of the receptors being occupied. To determine the presence of spare receptors, scientists often compare the concentration of the drug needed to produce 50% of the maximum effect (EC50) with the concentration of the drug needed to occupy 50% of the receptors (Kd). If the...
3.5K
Adrenergic Receptors: β Subtype
1.6K
β-adrenoceptors have varied sensitivities towards adrenaline, noradrenaline, and isoprenaline. The order of agonist potency is as follows:
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
1.6K


