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移植中的治疗性非:新兴趋势
Chimezie Godswill Okwuonu1,2, Monarch Shah1, Iram Rafique1
1Division of Nephrology, University of Virginia Health, Charlottesville, Virginia, USA.
Journal of clinical apheresis
|May 6, 2024
概括
治疗性非 (TA) 越来越多地用于移植,主要用于抗体介导的排斥. 虽然出现了不良事件,但它们是轻微的,患者的生存率保持在预期的范围内.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 移植免疫学 移植免疫学
- 传感医学 传感医学 传感医学
背景情况:
- 治疗性阿菲雷斯 (TA) 是移植中至关重要的治疗方法,其利用率正在显著增长.
- 这项研究考察了TA指标,不良事件和移植队列中的患者结果的当前趋势.
研究的目的:
- 分析移植受体治疗性非症 (TA) 指示的最新趋势.
- 为了评估与TA相关的安全概况和患者结果,在这个人群中.
主要方法:
- 从2017年1月1日到2022年12月31日进行了回顾性队列审查.
- 数据包括患者人口统计数据,TA指示,手术细节,不良事件和生化标志物.
- 使用SPSS 2022进行了统计分析.
主要成果:
- 总共有131名患者接受了860次TA手术.
- 对TA的首要症状是抗体介导排斥 (65.5%),其次是复发的FSGS (15%) 和TMA (5%).
- 在16.7%的手术中发生了不良事件,其中低血症是最常见的 (7%). 总体病例死亡率为8.4%.
结论:
- 抗体介导的排斥是TA在移植中的主要指示.
- 在移植患者中,TA与轻微的不良事件和可接受的患者存活率有关.
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