在脊椎手术后治疗术后疼痛的特拉马多尔-青 - 一项随机,双盲,安慰剂控制的随机研究
Emma Lappalainen1, Jukka Huttunen2, Hannu Kokki1
1Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Scandinavian journal of pain
|May 6, 2024
概括
将特拉马多尔 - 青添加到多模式疼痛管理中并没有改善脊椎手术后的患者满意度. 接受特拉马多尔 - 青的患者经历了更多的不良事件,但没有增强疼痛缓解.
科学领域:
- 整形外科 整形外科 整形外科
- 疼痛管理 疼痛管理
- 术后恢复 术后恢复
背景情况:
- 多种模式的疼痛管理对于改善手术后恢复 (ERAS) 协议至关重要.
- 评估特定止痛药组合的疗效对于优化术后护理至关重要.
研究的目的:
- 评估特拉马多尔 - 青作为治疗急性术后疼痛的补充疗法的疗效.
- 确定特拉马多尔 - 青对疼痛结果和脊柱手术后12个月的患者满意度的影响.
主要方法:
- 一个随机,双盲,安慰剂对照试验,涉及120名接受脊椎手术的患者.
- 患者在术后5天内接受了特拉马多尔-白醇或安慰剂,同时接受了标准的多模式止痛药 (德克塞托,氧,布洛芬).
- 疼痛,止痛药的使用和满意度被评估在基线,1周和52周使用简要疼痛清单问卷.
主要成果:
- 一周后患者对止痛药的满意度在特拉马多尔 - 青和安慰剂组之间是相似的 (70%与75%,p=0.949).
- 特拉马多尔- acetamol组需要更高剂量的布洛芬 (800mg与200mg,p=0.016) 和报告了更多的不良事件 (RR=1.8).
- 两组之间在需要救援氧化时没有发现显著差异.
结论:
- 补充治疗的特拉马多尔-青并没有改善患者对脊椎手术后早期疼痛管理的满意度.
- 研究结果表明,特拉马多尔-青在这种情况下可能不会提供额外的益处,并且与增加的不良事件有关.
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