绘制课程:对美国神经内分泌瘤动态的洞察
Christopher Wu1, Zhixing Song1, Sanjana Balachandra1
1Department of General Surgery, University of Alabama at Birmingham, Birmingham, AL.
Annals of surgery
|May 6, 2024
概括
神经内分泌瘤 (NET) 发病率从1975年到2020年翻了四倍,在2020年略有下降. 高度瘤,单一患者和黑人患者的生存结果较差.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 神经内分泌瘤 (NETs) 的发病率和患病率呈上升趋势.
- 更新的流行病学数据对于临床策略和公共卫生倡议至关重要.
- 了解NETs不断变化的格局需要最新的信息.
研究的目的:
- 探索神经内分泌瘤 (NETs) 流行病学的变化趋势和特征.
- 分析人口统计,临床方面和生存模式.
- 研究健康的社会决定因素 (SDOH) 对NET结果的影响.
主要方法:
- 使用SEER数据 (1975-2020) 进行回顾性,基于人口的研究.
- 计算年龄调整的发病率,流行率和5年整体存活率.
- 使用癌症特异性死亡率的细灰色模型检查了生存趋势 (2000-2019).
主要成果:
- 年龄调整后的NET发病率从每10万人口中的1.5到6.0增长了四倍 (1975-2020),并于2020年下降.
- 高等级 (HR: 2.95),单身患者 (HR: 1.49) 和黑人患者 (HR: 1.17) 的生存率较差.
- 根据患者的特征,观察到生存率的显著差异.
结论:
- 净发病率稳步增加到2019年,随后在2020年下降.
- 识别这些流行病学趋势的驱动因素对于管理和规划至关重要.
- 需要进一步的研究,以提高对NET流行病学和影响因素的理解.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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