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在早产新生儿的抗生素持续时间和胃不运动
Liane Samira Sadder1, Larry Steven Brown2, Lindsay Roblyer3
1Division of Pediatric Gastroenterology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, Texas, USA.
概括
在早产婴儿中长期使用抗生素并没有显著改变胃节律失常 (胃节律失常). 需要使用更大的样本大小进行进一步的研究,以证实新生儿护理中的这一发现.
科学领域:
- 新生儿生理学 新生儿生理学
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 长时间使用抗生素与新生儿食不耐症和功能性胃肠道疾病 (FGIDs) 有关.
- 胃节律失常,特别是通过电胃学 (EGG) 测量的胃节律失常 (>4-9周期/分钟),与FGID相关.
研究的目的:
- 调查长时间暴露于抗生素和早产婴儿的胃节律失常之间的关系.
- 为了在接受长 (>48小时) 和短 (≤48小时) 抗生素疗程的早产婴儿之间比较每周变化,以评估早期发作的败血症.
主要方法:
- 88名早产婴儿 (<34周怀孕) 的前性队列研究.
- 从出生到40周的月经后年龄的每周电气胃镜 (EGG) 记录.
- 混合效应模型用于评估抗生素暴露组之间的%分泌的差异.
主要成果:
- 在9周的产后期,在短时间和长时间的抗生素暴露组之间没有观察到太基胃的百分比显著差异 (p=0.08).
- 两组的基线特征在两组之间是相似的.
结论:
- 在早产婴儿中,早期,长时间的抗生素暴露可能不会显著诱导胃节律失常.
- 需要对"没有抗生素"对照组进行更大规模的研究,才能充分理解这种关系.
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