在健康衰老的背景下,探索牙脱落,认知功能和大脑健康之间的联系
Roger D Newman-Norlund1, Santosh Kudaravalli1, Anwar T Merchant2
1Department of Psychology, College of Arts and Sciences, University of South Carolina, Columbia, South Carolina, USA.
Journal of periodontal research
|May 6, 2024
概括
磁力共振成像 (MRI) 衍生牙计数显示,与健康成年人的认知功能有很强的联系. 这一措施可以改善认知能力的预测,突出口腔健康和大脑健康之间的联系.
科学领域:
- 神经科学是一个神经科学.
- 口腔健康研究研究 口腔健康研究
- 认知老龄化 认知老龄化
背景情况:
- 口腔和牙周健康越来越被认为是影响全身健康的因素,包括神经功能.
- 脑年龄差距 (BAG) 是一种来自MRI的测量方法,它量化了脑部过早衰老,并与认知能力下降有关.
- 牙数等口腔健康指标与健康成年人的认知表现之间的关系需要进一步研究.
研究的目的:
- 评估MRI衍生的牙总数和大脑年龄差距 (BAG) 对健康成年人的认知功能的预测效用.
- 确定MRI衍生牙计数是否可以提高认知得分的预测,特别是蒙特利尔认知评估 (MoCA).
主要方法:
- 追溯分析来自老化大脑队列库的329名健康成年人的数据.
- 参与者接受了神经心理测试 (MoCA),完成了口腔健康问卷,并接受了结构性MRI扫描.
- 认知得分与MRI衍生的BAG,MRI衍生的牙总数和自我报告的口腔健康相关分析.
主要成果:
- 在总牙数和MoCA分数 (r=0.233,p<0.001) 之间发现了显著的正相关性,独立于年龄,性别和种族.
- 在一个患有轻度认知障碍 (MCI) 的风险小组中,基于MRI的牙计数显著改善了MoCA得分预测 (R2变化=0.192,p=0.006).
- 大脑年龄差距 (BAG) 在线性回归模型中没有显著提高MoCA得分的预测.
结论:
- 磁力共振成像 (MRI) 衍生的牙总计数显示为预测健康成年人的临床相关认知差异的工具.
- 这些发现加强了口腔健康和认知功能之间的联系,表明牙计数作为潜在的生物标志物.
- 需要进一步的研究来探索口腔健康和认知衰老之间的关联背后的机制.
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