对接受脏和非脏移植的接受者的病毒检测负担和频率
Hema Kapoor1, Caixia Bi2, Martin H Kroll3
1Infectious Diseases/Immunology, Quest Diagnostics, Secaucus, New Jersey, USA.
Microbiology spectrum
|May 6, 2024
概括
移植后的传染病检测频率往往不足于推的指导方针,影响了患者的护理. 这项研究突出了脏和非脏移植接受者的坚持差距.
科学领域:
- 移植 传染病 移植 传染病
- 临床实验室科学 临床实验室科学
- 公共卫生监督 公共卫生监督
背景情况:
- 移植接受者面临由于免疫抑制而增加的感染风险.
- 已建立的移植后检测指南旨在监测和管理这些感染.
- 在遵守测试协议方面可能存在变化.
研究的目的:
- 评估对移植后传染病的建议实验室检测频率的遵守情况.
- 通过使用国家参考实验室数据,将实际的测试模式与已发布的指南进行比较.
- 发现患者接受和遵守分子传染病测试 (MIDT) 的差距.
主要方法:
- 从2019年1月到2020年12月,对345名移植患者 (脏和非脏) 的国家参考实验室数据进行分析.
- 纳入标准:ICD-10移植代码,2019年1月7天内至少进行两次测试,2020年12月进行一次测试.
- 对MIDT的排序模式,阳性率和测试频率的评估,包括BK病毒 (BK),细胞巨血病毒 (CMV) 和爱斯坦-巴尔病毒 (EBV).
主要成果:
- 所有患者的测试间隔随着时间的推移而增加.
- 超过40%的移植接受者 (KTR) 和20%的非KTR接受者比EBV和BK病毒的指导方针测试频率少.
- 在KTR (58%) 和非KTR (64%) 中,尿液BK病毒 (uBKV) 的阳性率最高.
结论:
- 遵守用于移植后传染病的推测试频率是不理想的.
- 实际的测试实践与公布的KTR和非KTR指南之间存在差异.
- 结果可以为标准化移植监测策略和改善患者治疗结果的努力提供信息.
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