患有高血压的儿童和青少年的长期心血管结果
Cal H Robinson1,2, Junayd Hussain3, Nivethika Jeyakumar4
1Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada.
JAMA pediatrics
|May 6, 2024
概括
患有高血压的儿童在以后的生活中面临重大不良心脏事件 (MACE) 的风险增加了一倍. 儿童高血压的早期检测和管理对于预防成人心血管疾病至关重要.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 儿童高血压的患病率正在上升,追踪到成年期.
- 已知相关的亚临床心血管疾病,但长期结果尚不清楚.
- 这种差距可能导致小儿高血压的诊断不足和治疗不足.
研究的目的:
- 评估诊断为高血压的儿童长期发生重大心脏不良事件 (MACE) 的风险.
- 提供证据,将儿童高血压与未来心血管结果联系起来.
主要方法:
- 在加拿大安大略省进行基于人口的,追溯的,匹配的队列研究 (1996-2022年).
- 包括3-18岁的患有事件高血压的儿童,与5个对照组相匹配.
- 使用行政卫生数据库进行诊断和结果跟踪.
主要成果:
- 25,605名患有高血压的儿童与128,025名对照进行了匹配.
- 随访时间平均为13.6年;MACE发生率为4.6对每1000人年2.2人.
- 高血压儿童患MACE的风险增加了2.1倍,包括中风和心力衰竭.
结论:
- 患有高血压的儿童长期患有MACE的风险明显更高.
- 改善儿科高血压的检测和管理可以减轻成人心血管疾病的风险.
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