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年轻成年男性的抗抑郁药不坚持和性功能障碍:横截面YAMAN研究
Matthew J Rabinowitz1, Oscar Li2, Ellen H Pil2
1Division of Urology, Department of Surgery, University of Pennsylvania, Philadelphia, PA, USA.
World journal of urology
|May 6, 2024
概括
如果抗抑郁药引起性功能障碍,年轻男性不太可能坚持服用抗抑郁药. 他们更喜欢像布洛普里昂或米尔塔扎这样的药物,可以节省性功能,强调需要以患者为中心的策略.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 药理学 药理学是指药理学的学科.
- 男人的健康 男人的健康
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是常见的抗抑郁药.
- SSRI与严重的不坚持性和性功能障碍相关.
- 性副作用对年轻成年男性抗抑郁药坚持的影响尚不清楚.
研究的目的:
- 调查年轻成年男性性功能障碍和抗抑郁药不坚持之间的相关性.
- 评估年轻成年男性在面临性副作用时是否愿意坚持抗抑郁药治疗.
主要方法:
- 进行了一项补偿,无身份调查,以评估人口统计,抑郁症 (PHQ-8),焦虑症 (GAD-7),以及对抗抑郁药副作用的态度.
- 参与者评估了对SSRI,布罗和米尔塔扎的看法,包括常见的副作用概况.
- 根据副作用概况,评估了坚持不同类型抗抑郁药的意愿.
主要成果:
- 在505名受访者中,486人被纳入最终分析.
- 与SSRI相比,年轻男性更愿意使用性功能节约剂 (布普罗,米尔塔扎平) (p < 0.001).
- 性功能障碍 (勃起功能障碍,异能症) 被认为比其他副作用 (如体重增加或恶心) 更有影响力.
结论:
- 抗抑郁药的性副作用在年轻成年男性中构成不坚持性行为的重大风险.
- 使用性功能节约剂可能会改善坚持性.
- 共享决策和替代药物策略对于优化抗抑郁药物的有效性和坚持是至关重要的.
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