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在1型肌性缩症中认知障碍的异质性是由三个不同的认知概况解释的

Jean-Baptiste Davion^1,2,3,4, Céline Tard^5,6,7, Loren Fragoso⁷

¹U1172-LilNCog-Lille Neuroscience & Cognition, Univ. Lille, Inserm, CHU Lille, 59000, Lille, France. jeanbaptiste.davion@chru-lille.fr.

Journal of neurology

|May 6, 2024

概括

在1型肌性发育不良症 (DM1) 中的认知障碍有所不同,并确定了不同的特征. 这些由年龄和疾病持续时间影响的个人资料有助于解释研究不一致性,并表明成年DM1患者的神经退行.

科学领域:

神经学神经学
神经心理学神经心理学
遗传学是一个遗传学.

背景情况:

在1型肌性发育不良症 (DM1) 中的认知障碍在研究中显示出显著的异质性.
这种变异性表明DM1人口中存在不同的认知特征.

研究的目的:

识别和描述成年DM1患者的不同认知特征.
调查与这些认知概况相关的临床,生物和行为因素.

主要方法:

124名成人DM1患者接受了全面的临床,神经心理和行为评估.
对9项认知测试进行了K-means聚类分析,评估了记忆,视觉构造能力,认知,执行功能和处理速度.

主要成果:

在124名DM1患者中发现了三个不同的认知集群.
集群1显示认知能力受到保护;集群2显示执行功能受损;集群3显示出更明显的,扩散的缺陷.
年轻的年龄,最近的临床发病和高等教育与更好的认知功能相关 (集群1).

结论:

在成年DM1患者中存在不同的认知概况,受年龄和疾病持续时间的影响.
这些发现可能会解决以前DM1认知研究中的差异.
结果表明,在成年DM1中存在潜在的神经退行过程.

关键词:

集群集群集群集群认知认知是一种认知.肌肉病症肌肉病症是指肌肉病症.肌性发育不良症肌性发育不良症肌性发育不良症斯泰因特病是斯泰因特病的一种疾病.

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