氧化层次的花样COF用于在牛奶中固相提取上腺素受体激活剂
Guiju Xu1, Chuqing Liu2, Chunlei Yang3
1Institute of Food & Nutrition Science and Technology, Shandong Academy of Agricultural Sciences, Jinan, China. xuguiju2013@126.com.
Mikrochimica acta
|May 6, 2024
概括
使用含LC-MS/MS的氧化共价有机框架 (COF) 的新型检测平台有效地识别了牛奶中的上腺素受体激动剂 (ARA) 残留物,提供了一种新的分析方法.
科学领域:
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
- 食品安全 食品安全
背景情况:
- 上腺素受体激动剂 (ARA) 在畜牧业中使用,需要敏感的检测方法来检测牛奶等食品中的残留物.
- 目前的检测方法可能缺乏对综合残留物分析所需的灵敏度或效率.
- 共价有机框架 (COF) 为高级分离和检测应用提供可调节的特性.
研究的目的:
- 开发和验证一种新的检测平台,以检测牛奶中的上腺素受体激动剂 (ARA) 残留物.
- 使用一种新的化共价有机框架 (COF) 进行固相提取 (SPE),并配合LC-MS/MS.
- 为了研究ARAs在氧化COF材料上的吸附机制.
主要方法:
- 通过特定有机前体的聚合合成化COF的合成.
- 合成的COF在固体相提取 (SPE) 中用于制备牛奶样本的应用.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 检测和定量α2-和β2-ARA残留物.
- 使用模型配件和分子模拟探索吸附机制.
主要成果:
- 开发出来的氧化COF表现出一个层次的花样形态,丰富的活性吸附点.
- 检测平台成功地在牛奶样本中发现了四个α2-和五个β2-ARA的残留物.
- 达成的ARA线性范围为0.25至50μg·kg−1,具有良好的日内 (2.9-7.9%) 和日间 (2.0-10.1%) 可重复性.
- 该COF材料显示出作为有效的SPE弹包装材料的巨大潜力.
结论:
- 基于氧化COF的SPE与LC-MS/MS相结合,提供了一种可靠而敏感的方法来确定牛奶中的ARAs残留物.
- 这种方法提供了一种有价值的新工具,用于确保食品安全,并监测乳制品行业中ARA的滥用情况.
- 该研究强调了定制COF在开发复杂矩阵的先进分析平台方面的潜力.
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