过氧对肌肉交感神经活动的影响:系统性审查和元分析
Desmond A Young1, Paris A T Jones1, Brittany A Matenchuk1,2
1Neurovascular Health Lab, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada.
概括
过氧症不会影响健康个体的交感神经活动. 然而,在那些患有慢性疾病的人中,高氧症显著降低了同情活动,而更高的休息活动预测了更大的减少.
科学领域:
- 生理学 生理学 生理学
- 心血管科学 心血管科学
- 神经科学是一个神经科学.
背景情况:
- 肌肉交感神经活动 (MSNA) 是心血管功能的关键调节者.
- 了解高氧化对MSNA的影响对于管理各种临床条件至关重要.
- 以前的研究已经产生了关于高氧化对MSNA的影响的相互矛盾的结果.
研究的目的:
- 进行一项元分析,评估高氧化对MSNA的影响.
- 为了比较健康个体与心脏代谢疾病患者之间的这些影响.
主要方法:
- 在电子数据库中进行了系统的文献搜索,直到2022年8月.
- 包括研究涉及人类参与者,暴露于高氧或高压,并测量MSNA,心率,血压或通风.
- 49项研究被纳入最终的元分析.
主要成果:
- 在健康个体中,高氧症并没有显著改变MSNA参数 (爆发频率,发生率,振幅或总活动).
- 在患有慢性疾病的个体中,高氧症显著降低了MSNA爆发的频率和发生率.
- 过氧症在两组人群中降低了心率,但没有影响血压.
结论:
- 过氧症在健康人群中不会改变交感神经活动.
- 相比之下,高氧化明显降低了慢性疾病患者的同情活动.
- 休息时的交感活动水平预测了高氧化下MSNA减少的程度.
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