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辅助化疗对局部脱差低级骨髓瘤的影响:系统性审查

S Tsukamoto¹, A Righi², A F Mavrogenis³

¹Department of Orthopedic Surgery, Nara Medical University, 840, Shijo-Cho, Kashihara-City, Nara, 634-8521, Japan. shinji104@mail.goo.ne.jp.

Musculoskeletal surgery

|May 6, 2024

概括

辅助化疗对局部非分化低度骨髓瘤的疗效有限. 仅广泛切除似乎就死亡率和复发率而言,与切除加化疗相当.

科学领域:

在瘤学瘤学.
整形外科手术整形外科手术
癌症研究癌症研究

背景情况:

不分化的低度骨髓瘤是高度恶性瘤.
这些瘤可以来自骨和低度骨髓瘤.
治疗通常涉及广泛的切除,具有有争议的辅助化疗疗效.

研究的目的:

系统地审查有关死亡率和复发/转移率的研究.
为了比较局部脱差低级骨肉瘤的宽切除与宽切除加化疗.

主要方法:

对Embase,PubMed和Cochrane数据库进行系统审查.
包括7项追溯研究,涉及114名患者.
没有确定随机对照试验.

主要成果:

死亡率:20.3% (切除+化疗) 与11.4% (仅切除) 相比.
复发/转移率:36.7% (切除+化疗) 与28.6% (仅切除) 相比.
两组之间结果没有显著差异 (P > 0.05).

结论:

辅助化疗在局部非分化低度骨髓瘤中表现出有限的疗效.
该审查强调了未来随机对照试验的必要性,因为研究的局限性.

关键词:

一个辅助的辅助.化疗化疗是一种化学疗法.没有分化,没有分化.低度的中心骨质肉瘤骨骨髓骨肉瘤是一种骨骨肉瘤.

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