测量抑郁症试验中的生活质量:一个全面的综述
Wade Thompson1, Carina Lundby2,3, Adam Bleik4
1Department of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, University of British Columbia, 317-2176 Health Sciences Mall, Vancouver, BC, V6T 2A1, Canada. Wade.thompson@ubc.ca.
Drugs & aging
|May 6, 2024
概括
这次审查发现,虽然生活质量 (QoL) 尺度用于抑郁症试验,但它们可靠捕捉变化的能力是不确定的. 需要进一步的研究来确定最佳的QoL测量工具来减少干预.
科学领域:
- 老年学和老年医学是老年学和老年医学.
- 临床药学和药理学 临床药学和药理学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 生活质量 (QoL) 是评估抑郁症治疗干预措施的关键结果.
- 现有的QoL测量工具可能无法充分捕捉因抑郁症而产生的变化.
- 老年人经常经历多种药物治疗,需要有效的抑郁症处方策略.
研究的目的:
- 在老年人抑郁症临床试验中对生活质量 (QoL) 测量进行范围审查.
- 识别和评估用于减压和多药减少研究的QOL尺度.
- 为未来的描述性研究选择合适的QOL措施提供信息.
主要方法:
- 在多个数据库 (MEDLINE,Embase,PsycINFO等) 中进行全面的文献搜索. 在2023年10月之前.
- 包括随机和非随机对65岁以上成年人抑郁症/多药性减少的比较研究.
- 包括与药物负担相关的18岁以上成年人QOL尺度开发/验证研究.
- 系统选,由独立审查员提取数据,并使用COSMIN检查清单进行批判性评估.
主要成果:
- 包括52项研究:44项描述性试验和8项规模开发研究.
- 确定了21种QOL尺度 (12种通用,9种药物特定);通用EQ-5D变异是最常见的.
- 现有尺度的测量特性,以捕捉从抑郁的QoL变化是不确定的.
- 药物特异性QOL尺度尚未用于抑郁症的临床试验,因此其实用性尚不清楚.
结论:
- 现有的QoL尺度已应用于减压试验,但它们在可靠测量影响方面的有效性尚不确定.
- 已经提出了新的药物特定的QoL尺度,但尚未在抑郁症下文中进行测试.
- 研究人员和临床医生在选择 QoL 测量方法时,应仔细考虑尺度属性.
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