县级的阿特拉辛使用和胃
Sunaya R Krishnapura1,2, Elizabeth McNeer2,3, William D Dupont2,3
1Vanderbilt University School of Medicine, Nashville, Tennessee.
JAMA network open
|May 6, 2024
概括
在各县增加的农药阿特拉津的使用与高发胃,一个先天缺陷的比率有关. 这项研究表明,由于潜在的健康问题,在美国探索阿特拉辛的替代品可能是有必要的.
科学领域:
- 环境健康 环境健康
- 儿科健康 儿科健康
- 毒理学 毒理学 毒理学
背景情况:
- 自20世纪60年代以来,美国的胃分裂发病率一直在上升.
- 杀虫剂阿特拉是疑似原因,但研究有限.
研究的目的:
- 评估国家胃病发病率趋势.
- 确定与胃症相关的母亲和婴儿特征.
- 检查县级阿特拉辛使用与胃症之间的关联.
主要方法:
- 使用美国出生证明数据 (2009-2019) 进行回顾性,重复的横截面研究.
- 分析包括来自美国地质调查局的县级阿特拉津使用数据.
- 混合效应后勤回归模型评估了阿特拉津暴露与胃发生率之间的关联.
主要成果:
- 分析了3900多万例分娩;确定了10,527例胃.
- 患有胃的婴儿的母亲具有特定的人口统计和健康状况.
- 较高的县级阿特拉辛使用与增加的胃发生率 (AORs从1.12到1.21) 有显著的关联.
结论:
- 较高的县级阿特拉津水平与婴儿胃病诊断的增加相关.
- 阿特拉津是美国广泛使用的除草剂,在其他国家由于健康问题而被禁止使用.
- 这些发现支持在美国探索阿特拉辛替代品.
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