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哺乳动物细胞基因毒性饮用可重复使用和传统饮用水

Stephanie S Lau¹, Katherine Bokenkamp^2,3, Aleksander Tecza^2,3

¹Department of Civil and Environmental Engineering, Stanford University, 473 Via Ortega, Stanford, California 94305, United States.

Environmental science & technology

|May 6, 2024

概括

使用基因毒性测试来评估可饮用再利用水质量. 反透处理有效降低了基因毒性,产生了比传统来源更安全的饮用水,突出了评估未知的污染物的必要性.

科学领域:

环境科学环境科学
毒理学毒理学毒理学
水处理处理水的方法

背景情况:

饮用可再生水对于水资源稀缺地区的供水至关重要.
毒性测试对于评估再利用水的安全性至关重要.
消毒副产品 (DBP) 和人为污染物是再利用水的关键问题.

研究的目的:

为了评估可饮用再利用水的基因毒性.
为了比较不同处理列车的有效性,包括反透 (RO).
确定各种污染物对整体基因毒性的贡献.

主要方法:

中国仓鼠卵巢 (CHO) 细胞急性直接基因毒性试验.
用RO处理和无RO处理的水处理列车的比较.
与当地的传统饮用水进行基准测试.

主要成果:

基于RO的处理列车在减少废水的基因毒性方面更有效.
经过RO处理的再利用水的基因毒性低于地表水来源的自来水.
非挥发性,无特征的DBP和人为污染物导致基因毒性 (≥73%),超过已知的 (半) 挥发性DBP (2-27%).
不受管制的DBPs比受管制的更具基因毒性.

结论:

反透是一种高效的治疗方法,可降低饮用水的基因毒性.
整个水的毒性评估至关重要,考虑到不具特征的污染物.
仅仅关注已知 (半) 挥发性DBP是不够的,以确保水安全.

关键词:

生物测试生物测试消毒副产品的消毒方法遗传毒性遗传毒性遗传毒性遗传毒性饮用饮料可重复使用.反透的反透是什么意思

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