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Updated: Jun 27, 2025

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Published on: April 26, 2017

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UPF1螺旋酶与SMG6内核酶和UPF2进行相互排斥的相互作用

Lukas M Langer1, Katharina Kurscheidt1, Jérôme Basquin1

  • 1Department of Structural Cell Biology, Max Planck Institute of Biochemistry, Martinsried/Munich D-82152, Germany.

Nucleic acids research
|May 6, 2024
PubMed
概括

无意中介的mRNA衰变 (NMD) 使用UPF1来招募SMG6来降解有缺陷的mRNA. 这项研究揭示了SMG6结合UPF1的基因,但只有当UPF1与UPF2不结合时,才能清楚地说明NMD调节.

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