立方体的使用和乳腺癌复发和死亡率的风险
Hanbing Guo1,2, Kathleen E Malone1,2, Susan R Heckbert2
1Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Cancer
|May 6, 2024
概括
乳腺癌诊断后使用他类药物并没有影响复发风险,但与改善癌症特异性存活率有关. 需要进一步的随机试验来确认乳腺癌患者的这些发现.
科学领域:
- 在瘤学瘤学.
- 心血管药理学心血管药理学
背景情况:
- 在观察性研究中,关于他类药物的使用和乳腺癌存活率存在相互矛盾的结果.
- 临床前数据表明,他类药物可能会改善乳腺癌患者的治疗结果.
研究的目的:
- 评估乳腺癌诊断后使用他类药物与癌症结局之间的关联.
- 评估诊断后使用他类药物对乳腺癌复发和死亡率的影响.
主要方法:
- 从SEER-Medicare数据中对38858名年龄≥66岁,患有局部/区域性乳腺癌的妇女进行了回顾性队列研究 (2008-2017年).
- 通过医疗保险D部分药房声明确定他类药物的使用.
- 用于分析复发和乳腺癌特异性死亡风险的多变量考克斯比例危险模型.
主要成果:
- 诊断后使用他类药物与乳腺癌复发风险增加无关 (HR,1.05;95% CI,0.91-1.21)
- 诊断后使用他类药物与乳腺癌特异性死亡率降低的风险有关 (HR,0.85;95% CI,0.75-0.96).
- 在患有激素受体阳性/人表皮生长因子受体2-阴性乳腺癌 (HR,0.71;95% CI,0.57-0.88) 的妇女中观察到更显著的死亡率降低.
结论:
- 诊断后使用他类药物似乎与乳腺癌患者癌症特异性生存率的改善有关.
- 研究结果表明,他类药物对乳腺癌患者有潜在的益处.
- 建议进行随机试验,以验证这种人群中他类药物治疗的疗效.
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