麻种子蛋白及其水解剂与高血压成年人的蛋白消费相比:双盲交叉研究
Maryam Samsamikor1, Dylan S Mackay2, Rebecca C Mollard3
1Department of Food and Human Nutritional Sciences, Faculty of Agricultural and Food Sciences, University of Manitoba, Winnipeg, Manitoba, Canada.
大麻种子蛋白 (HSP) 和其生物活性 (HSP+) 在轻度高血压的成年人中显著降低了血压 (BP). 这表明大麻蛋白在通过饮食来控制高血压方面可能发挥作用.
科学领域:
- 营养科学 营养科学
- 心血管健康 心血管健康
- 人体生理学 人体生理学
背景情况:
- 缺乏研究大麻种子蛋白 (HSP) 和其生物活性水解剂 (HSP+) 对血压 (BP) 的影响的人类研究.
- 通过饮食干预来管理高血压是一个重要的公共卫生问题.
研究的目的:
- 研究HSP和HSP+消费对24小时内缩 (SBP) 和腹缩血压 (DBP) 的影响.
- 评估HSP和HSP+对与血压调节相关的血生物标志物的影响,与素相比.
主要方法:
- 一个双盲,随机,交叉试验,涉及35名轻度高血压的成年人.
- 参与者每天摄入50g的素,每天50g的HSP或每天45g的HSP+5g的HSP+6周,每周两周的洗期.
- 使用线性混合模型与重复测量分析了治疗效应.
主要成果:
- 与素相比,HSP+消费显著减少了24小时的SBP和DBP (P < 0.0001).
- 与素相比,HSP的消费也显著减少了24小时的SBP和DBP (P < 0.0001).
- 与素相比,HSP和HSP+治疗都降低了血血管酶转化酶 (ACE) 和素活性,同时增加了氧化 (NO) 度.
结论:
- 单独或与生物活性一起食用大麻种子蛋白质可能有助于通过饮食管理高血压.
- 进一步的研究可以探索大麻蛋白对心血管健康的特定机制和长期影响.
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