产前克制压力会影响小鼠幼早期的神经行为反应和氧化压力
Oumaima Essaidi1, Meriem Laaroussi1, Hafsa Malqui2
1Biological Engineering Laboratory, Faculty of Sciences and Techniques, Sultan Moulay Sliman University, Beni Mellal, Morocco.
Behavioural brain research
|May 6, 2024
概括
在小鼠中产前压力会对母亲的行为产生负面影响,并导致后代显著的神经发育障碍. 这些包括反射变化,学习缺陷和大脑化学变化,导致终身健康问题.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 产前压力 (PS) 对母亲和胎儿健康构成风险,改变发育并增加对终身健康问题的易感性,包括精神疾病.
- 抑制压力是一种常见的方法,可以在动物模型中诱导产前压力,而不会造成持久的伤害.
研究的目的:
- 在瑞士白色小鼠中调查产前克制压力 (PRS) 的特定神经发育和行为后果.
- 为了确定孕期PRS暴露导致的母体和后代的生理变化.
主要方法:
- 怀孕的瑞士白色老鼠从胚胎7.5天直到分娩时每天都受到克制压力.
- 评估了母亲的行为 (哺乳,,理,筑巢,养幼) 和后代的神经发育反射 (直立反射,避风险,负地质,游泳).
- 在后代的大脑中测量了包括马隆迪甲基 (MDA) 和乙胆酶 (AchE) 活性在内的生化标志物.
主要成果:
- 产前压力显著减少了母亲的体重增加,并影响了关键的母亲行为,如哺乳,和理.
- 暴露于PRS的后代表现出显著的神经行为缺陷,包括反射发育延迟和运动技能受损.
- 在压力大的小狗的大脑中观察到MDA活动增加和AchE活动减少,这表明氧化应激和神经传递改变.
结论:
- 产前克制压力会导致后代的深刻而持久的神经发育障碍.
- 这些障碍表现为改变母亲的照顾,显著的神经行为缺陷,以及发育中的大脑中的生化变化.
- 这些发现突出了发育中的大脑对产前压力的极大脆弱性,这可能对长期心理健康产生潜在影响.
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