冠状动脉疾病作为代谢功能障碍相关的脂肪性肝病和肝纤维化风险因素
Luis Vega1, Daniela Simian1, Abraham I Gajardo2
1Gastroenterology Section, Medicine Department, Hospital Clínico Universidad de Chile, Santiago, Chile.
Annals of hepatology
|May 6, 2024
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在冠状动脉心脏病 (CHD) 患者中很常见. 显著的CHD增加了肝纤维化的可能性,建议在这些患者中进一步调查.
科学领域:
- 心脏病学 心脏病学
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 患者面临心血管风险升高.
- 非酒精性脂肪性肝病 (NAFLD) 经常在冠状动脉心脏病 (CHD) 患者中观察到.
- 显著的心脏病和肝纤维化患病率之间的关系尚不清楚.
研究的目的:
- 确定患有心血管疾病的患者中MASLD和肝纤维化的发生频率.
- 评估冠状动脉狭窄严重程度与MASLD和肝纤维化之间的关联.
主要方法:
- 一项涉及113名成年患者的观察性研究,这些患者因疑似冠状动脉疾病而接受冠状动脉扫描.
- 显著的CHD定义为至少在一个冠状动脉中>50%的狭窄.
- 通过弹性扫描 (FibroScan®) 测量肝硬度,以评估肝纤维化 (>6.5 Kpa).
主要成果:
- 72%的患者患有显著的冠心病,52%患有MASLD.
- 肝纤维化存在于12%的患者中,特别是在显著的慢性心脏病组中更高 (p=0.007).
- 增加的冠状动脉狭窄与更高的肝纤维化概率相关 (OR1.79,p=0.029).
结论:
- 患有严重心脏病的患者中,MASLD非常普遍,即使没有先前的肝病诊断.
- 这些发现表明需要在心血管疾病患者中查MASLD和肝纤维化.
- 未来的研究应该探索混因素,如2型糖尿病.
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