儿科非传染性粒状卵膜炎:一个回顾性队列研究
Ai Tien Nguyen1, Antoine Rousseau2,3, Bahram Bodaghi4
1Department of Paediatric Rheumatology, CeRéMAIA, ERN RITA Member, Bicêtre University Hospital, Assistance Publique-Hôpitaux de Paris, Paris-Saclay University, Le Kremlin-Bicêtre, France.
Rheumatology (Oxford, England)
|May 6, 2024
概括
儿科颗粒状脑膜炎 (PGU) 是一种罕见的疾病,通常是晚诊断的,导致视力差. 这项研究强调异常和形形式是严重的,需要早期的疾病修饰疗法以获得更好的结果.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 儿科医学 儿科医学
背景情况:
- 儿科颗粒状脑膜炎 (PGU) 是一种罕见的疾病,具有重大诊断挑战和可能导致视力不佳的结果.
- 缺乏意识有助于延迟诊断和PGU的管理困难.
研究的目的:
- 评估儿科非传染性颗粒状脑膜炎的人口统计,病因,并发症,治疗和视觉预后.
- 为了解决这种罕见的儿科疾病的管理提供了洞察力.
主要方法:
- 对16岁以下儿童非传染性PGU病例的回顾性图表审查.
- 来自法国比克斯特尔医院 (2001-2023) 儿科风湿病学科的数据.
主要成果:
- 这项研究包括50名患者 (90只眼睛);大多数病例是异常病 (29) 或肉类突症 (15).
- 肺膜炎 (56%),双边干扰 (84%) 和慢性疾病 (84%) 是常见的. 眼部并发症在诊断时影响了76%的眼睛.
- 系统性皮质类固醇 (72%) 和甲状腺素 (80%) 是主要治疗方法. 通过随访,在91%的眼睛中实现了缓解或不活跃的疾病.
结论:
- 这是PGU报告的最大队列,主要是异常病,并发症率高.
- 状和异常性帕努韦炎是严重的,需要早期启动疾病修饰疗法,以改善患者管理和视觉预后.
相关概念视频
Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
Pharmacokinetics in Pediatric Patients: Drug Excretion
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Acute Pyelonephritis II: Diagnostic Studies and Management
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...


