卵细胞冷保存对于患有子宫内膜异位症的妇女:理由,说明和生殖结果
Seung Joo Chon1, Byung Chul Jee2
1Department of Obstetrics and Gynecology, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea.
Clinical and experimental reproductive medicine
|May 6, 2024
概括
患有子宫内膜异位症的女性可能会在手术前受益于卵细胞冷保存,以保持生育能力. 个体化评估至关重要,特别是对于双边子宫内膜瘤或卵巢储备减少的人来说.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
背景情况:
- 子宫内膜异位症经常导致卵巢储备减少和卵细胞产量减少,手术干预往往会使情况恶化.
- 尽管卵细胞数量减少,但子宫内膜异位症患者的卵细胞质量仍然不受影响,这支持了优质胚胎的体外受精结果令人满意.
研究的目的:
- 评估卵细胞冷保存作为孕妇内膜异位症妇女进行或计划进行手术的生育保护策略.
- 确定特定的患者亚组,这些亚组是卵细胞冷保存最合适的候选人.
主要方法:
- 审查目前的指导方针和临床考虑在子宫内膜异位症患者的生育保存.
- 分析影响卵细胞冷保存决定的因素,包括子宫内膜瘤特征,手术史和卵巢储备标记.
主要成果:
- 建议对双边子宫内膜瘤 (>3厘米),手术后复发性子宫内膜瘤或单个卵巢的单边子宫内膜瘤的患者进行卵细胞冷保存.
- 对于小单侧子宫内膜瘤和良好的卵巢储量,或卵巢储量减少 (AMH < 0.5 ng/mL) 的患者,冷保存一般不建议.
结论:
- 由于各种疾病表现,个人评估对于在子宫内膜异位症患者的卵细胞冷保存的决定至关重要.
- 通过卵细胞冷保存保存生育能力的保护应强烈考虑患者显著减少的卵巢储备,可能需要延长的检索期.
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