来自内植物的抗微生物作为新疗法,用于对抗耐药病原体
Pragya Tiwari1, Shreya Thakkar2, Laurent Dufossé3
1Department of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea.
Critical reviews in biotechnology
|May 6, 2024
概括
抗菌素耐药性 (AMR) 是一个全球性的紧急情况. 本综述探讨了内植物和合成生物学作为对抗耐药病原体的新型治疗来源.
科学领域:
- 微生物学 微生物学
- 自然产品化学 自然产品化学
- 药物发现 药物发现 药物发现
背景情况:
- 抗菌素耐药性 (AMR) 构成了严重的全球健康威胁,由于过度使用抗生素以及人类,动物和环境健康的相互联系 (One Health Concept) 而加剧.
- 抗药性耐药性的流行率上升导致死亡率增加,治疗选择有限,经济负担很大.
- 迫切需要新型抗菌资源来打击耐药病原体或"超级细菌".
研究的目的:
- 综合审查新兴趋势,前景和发现从内生菌中发现抗菌素的挑战.
- 探索合成生物学 (SB) 在增强内生菌衍生抗菌素生产方面的潜力.
- 突出Endophytes作为对抗AMR的新疗法有前途的来源.
主要方法:
- 关于内植物,抗微生物药物和合成生物学的科学出版物的文献评论.
- 分析当前关于从内菌中发现天然产品中介药物的研究.
- 对合成生物学方法的评估,以提高内菌产生的化合物的产量.
主要成果:
- 内植物产生各种化学实体,具有强大的抗微生物活性,对各种病原体起作用.
- 合成生物学为工程内植物提供了有希望的策略,以提高抗微生物药物的产量和有效性.
- 源自内菌的抗微生物是自然产品药物发现的未经探索但重要的领域.
结论:
- 内植物是发现新型抗微生物药物的宝贵生物资源,以应对AMR危机.
- 合成生物学具有优化这些天然化合物的生产的巨大潜力.
- 进一步研究内菌衍生抗微生物及其通过SB的生产对于开发针对超级细菌的新疗法至关重要.
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