设计了一种新的通过皮肤传递抗生素的聚合物膜,该聚合物膜经由功能化的SBA-15中性填充剂修改
Mahya Samari1, Soheila Kashanian2,3, Sirus Zinadini1,4
1Department of Applied Chemistry, Faculty of Chemistry, Razi University, Kermanshah, Iran.
Scientific reports
|May 6, 2024
概括
这项研究开发了一种新型的聚硫膜,用于增强阿齐思罗米辛的输送. 优化的膜显著增加了药物释放,并显示出出色的生物相容性和可重复使用性.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 药物输送系统 药物输送系统
背景情况:
- 开发先进的药物输送系统对于提高治疗疗效至关重要.
- 聚硫 (PES) 膜为药物输送提供了潜力,但需要进行修改以提高性能.
研究的目的:
- 通过修改的不对称的聚乙硫 (PES) 膜来增强阿兹罗米辛的输送.
- 优化膜组成和制造参数,以改善药物释放和生物相容性.
主要方法:
- 用SBA-15和胺修饰的SBA-15 (SBA-Q) 修饰的不对称PES膜的制造.
- 优化关键参数:药物度,膜厚度,修饰剂百分比,聚合物百分比和孔隙制造者百分比.
- 使用扫描电子显微镜,水接触角度和抗拉强度测试进行表征.
主要成果:
- 优化膜 (17%的PES,2%的聚烯利,1%的SBA-15,0.5%的SBA-Q) 显著增加了阿兹罗米辛的释放 (906 mg/L与440 mg/L).
- 独特的膜结构带有密集的顶层和多孔的下层,促进了持续的释放,并充当了储水池.
- 已确认具有有前途的生物相容性,抗菌活性,血液相容性和组织完整性.
结论:
- 经过修改的PES膜系统有效地增强了在体外和体外阿齐思罗素的输送.
- 优化的膜具有出色的生物相容性,可重复使用性和持续药物输送应用的潜力.
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