治疗注意力缺陷多动性障碍的药物与患青光眼的风险增加有关
Rami Darwich1, Mahyar Etminan2, Bonnie He1
1Department of Ophthalmology and Visual Sciences, Dalhousie University, Halifax, NS, Canada.
Eye (London, England)
|May 6, 2024
概括
注意力缺陷多动症 (ADHD) 药物,如安非他命和阿托莫克赛丁,增加了闭角玻璃眼 (ACG) 的风险. 然而,甲基酸的使用与高风险的开角玻璃眼 (OAG) 有关.
科学领域:
- 眼科医生 眼科 眼科
- 药理学 药理学是指药理学的学科.
- 公共卫生 公共卫生
背景情况:
- 注意缺陷多动性障碍 (ADHD) 药物,包括原子素,甲基酸盐和安非他命,被广泛使用.
- 这些药物具有交感相仿性质,导致患有角闭光眼 (ACG) 史的患者有禁忌.
研究的目的:
- 在使用多动症药物的人群中,研究开发闭角玻璃眼 (ACG) 和开角玻璃眼 (OAG) 的风险.
- 为了比较使用阿托莫克西丁,甲基酸盐和安非他胺的患者之间的玻璃眼风险.
主要方法:
- 使用PharMetrics Plus数据库进行了回顾性队列研究,并进行了病例对照分析.
- 对ADHD药物的新用户进行了ACG或OAG发生率的跟踪,并选择了年龄匹配的对照进行分析.
- 使用条件后勤回归来调整混因素,并计算调整后的发病率比率 (aIRR).
主要成果:
- 这项研究确定了240,257名新的ADHD药物使用者.
- 经常使用阿托莫克西和安非他命的患者,出现ACG的调整后发病率比率 (aIRR) 显著更高.
- 甲基化物使用者在开发OAG时表现出更高的aIRR.
结论:
- 氨基胺和阿托莫克赛丁的使用与增加角闭光眼 (ACG) 的风险有关.
- 甲基酸的使用与较高的开放角光眼 (OAG) 风险有关.
- 由于ADHD药物的广泛使用,这些发现对公共卫生有重大影响.
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