肺腺癌中HNF4α,TTF-1和SMARCA4的表达模式:对临床病理学和遗传特征的影响
Hitomi Kawai1,2, Tamaki Miura3, Natsumi Kawamatsu1,2
1Department of Pathology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8574, Japan.
概括
肺腺癌中的HNF4α表达与不同的亚型和预后有关. HNF4α阳性,差分化的瘤与SMARCA4损失表明结果更差.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 遗传学 是一个遗传学.
背景情况:
- 肝细胞核因子4-α (HNF4α) 表达和SMARCA4损失与非终端呼吸单元 (TRU) 型肺腺癌有关.
- 在肺腺癌亚型中,HNF4α表达和SMARCA4损失之间的确切关系尚不清楚.
研究的目的:
- 澄清HNF4α表达,SMARCA4状态,组织学亚型和肺腺癌中驱动突变之间的关系.
- 调查HNF4α表达在不同组织学级肺腺癌的预后意义.
主要方法:
- 基于HNF4α阳性,TTF-1,SMARCA4表达,组织学和驱动突变的241个肺腺癌的分层.
- 在来自肺腺癌细胞系的瘤组织和异种移植中对HNF4α和SMARCA4进行免疫组织化学分析.
主要成果:
- 阳性HNF4α腺癌被分为变异性 (乳腺癌/肠癌/结合体) 和传统的非乳腺癌组.
- 非类组包括TRU型 (TTF-1阳性,EGFR突变) 和非TRU型 (SMARCA4损失,固体组织学,没有EGFR突变).
- 阳性HNF4α,差异化肺腺癌显示出最差的预后;A549细胞显示HNF4α阳性和SMARCA4损失.
结论:
- HNF4α阳性非性肺腺癌包括TRU类型和非TRU类型的病例.
- 非TRU型HNF4α阳性肺腺癌的特征是高度的表型和频繁的SMARCA4损失.
- A549细胞系作为HNF4α阳性,SMARCA4丢失的肺腺癌的代表模型.
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