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在胰腺癌患者中,身体功能作为化疗诱导的外周神经病变的预测因子

Kuan-Yin Lin^1,2,3, Po See Chen⁴, Cheng-Feng Lin^5,6

¹Department of Physical Therapy, College of Medicine, National Cheng Kung University, No.1, University Road, 701, Tainan, Taiwan.

BMC gastroenterology

|May 6, 2024

概括

化疗前的身体功能,特别是定时启动和启动 (TUG) 测试完成时间和罗姆伯格测试结果,可以预测胰腺癌患者的化疗诱导的外周神经病变 (CIPN) 严重程度. 这些测试对于早期评估至关重要.

科学领域:

在瘤学瘤学.
神经学神经学
临床研究临床研究

背景情况:

化疗诱导的周围神经病变 (CIPN) 是神经毒性癌症治疗的常见副作用.
化疗前的功能状态越来越被认为是CIPN严重程度的潜在预测因素.
关于胰腺癌患者在化疗前的身体功能和CIPN之间的关系的数据有限.

研究的目的:

在胰腺癌患者中确定CIPN的预测因子.
调查化疗前身体功能与CIPN发育和严重程度之间的关联.

主要方法:

来自209名胰腺癌患者的数据的二次分析.
在基线使用握力,定时启动和启动 (TUG),2分钟步骤测试 (2MST) 和罗姆伯格测试来评估身体功能.
在6个月的随访后使用CIPN20问卷对CIPN的评估.
多重线性回归分析以确定基线功能和6个月CIPN得分之间的关联.

主要成果:

基线TUG完成时间显著预测了6个月后的整体CIPN严重程度 (β=0.684,p=0.003).
此外,TUG完成时间与感官和自主CIPN子尺度相关.
一个积极的基线罗姆伯格测试在6个月内显著预测了运动神经病变的严重程度 (β=0.525,p=0.009).

结论:

化疗前的定时启动和启动 (TUG) 测试完成时间和罗姆伯格测试结果是CIPN严重程度的潜在预测因素.
在接受化疗的胰腺癌患者中,建议将TUG和Romberg测试纳入临床评估.
这些功能性评估可能有助于识别患有CIPN.的风险较高的患者.

关键词:

资产负债表的平衡情况化疗化疗是一种化学疗法.胰腺癌是一种胰腺癌.周围神经病变是一种神经病变.时间上升并进行测试.

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