导向放射治疗的正电子发射断层扫描技术的进展和未来方向:叙述性综述
Shahil Mehta1, Christine Yang1, Hossein Jadvar2
1Department of Radiation Oncology, Keck School of Medicine of University of Southern California, Los Angeles, CA, USA.
定子发射断层扫描 (PET) 成像通过改善瘤向来增强辐射疗法. 在PET放射追踪器和生物指导放射疗法 (BgRT) 中的进步有望实现更精确的癌症治疗,特别是在寡头转移性疾病中.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 医疗成像医学成像
背景情况:
- 阳位子发射断层扫描 (PET) 成像对于在放射治疗中划分瘤体积至关重要.
- 用PET指导放射治疗的领域正在迅速扩大,并准备对未来的放射治疗产生重大影响.
研究的目的:
- 提供关于PET导向放射治疗现状的全面概述.
- 探索PET导向放射治疗的未来方向和新兴技术.
主要方法:
- 一篇关于PubMed文章的叙事评论,这些文章在2010年至2023年之间发表.
- 关键词包括PET导向放射治疗,放射性追踪剂,寡头转移性疾病和生物导向放射治疗 (BgRT).
- 对搜索结果及其引用进行广泛的审查.
主要成果:
- 18F-2--2-脱氧-D-葡萄糖 (FDG) 是主要的PET放射追踪剂,可通过CT可视化代谢活跃的瘤.
- 新的放射性追踪剂可以改善瘤的特征 (新陈代谢,缺氧,血管性,扩散).
- 剂量绘画和自适应性放射治疗等技术提高了治疗选择性;PET线性加速器旨在将这些技术用于BgRT,特别是对于寡基转移性疾病.
结论:
- 用PET指导的放射疗法面临挑战,但正在迅速发展.
- 佩特成像技术将彻底改变放射治疗的方法.
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