在鼻腔手术全身麻醉后出现动荡时比较雷米萨佐拉姆和德斯弗卢兰:一项前性随机对照研究
Sung-Ae Cho1,2, So-Min Ahn1, Woojin Kwon1
1Department of Anesthesiology and Pain Medicine, Konyang University Hospital, Konyang University College of Medicine, Daejeon, Korea.
与德斯弗兰-氧化麻醉相比,雷米马佐拉姆-雷米芬坦尼尔麻醉显著降低了出现动荡. 这种方法还改善了血液动力学稳定性,并减少了术后窒息.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
背景情况:
- 雷米马佐拉姆是一种超短效的二甲类药物,对其在全静脉麻醉 (TIVA) 中的使用研究有限.
- 出现动荡 (EA) 是全身麻醉后的一个担忧,特别是在鼻腔手术后.
研究的目的:
- 为了比较基于Remimazolam的TIVA和desflurane麻醉之间的出现动荡 (EA) 的发生率和严重程度.
- 为了评估两种麻醉技术之间的血液动力学变化和术后窒息感.
主要方法:
- 一项前性随机受控研究,涉及76名接受鼻腔手术的患者.
- 患者被随机分配,接受德斯弗兰-氧化 (DN) 或雷米马佐拉姆-雷米芬坦尼尔 (RR) 来维持麻醉.
- 使用三个经过验证的尺度来评估出现动荡,以及血液动力学监测和术后窒息的评估.
主要成果:
- 雷米扎拉姆-雷米芬坦尼尔组在所有评估尺度上显示出EA的发生率明显较低 (P < 0.001).
- 两组之间观察到出现期间心率变化的显著差异 (P = 0.002).
- 术后窒息感的发生率在雷米马佐拉姆-雷米芬坦尼尔组较低 (P = 0.027).
结论:
- 雷米马佐拉姆-雷米芬坦尼尔麻醉有效地降低了经过鼻腔手术的患者出现激动的发生率和严重性.
- 这种麻醉方案在控制血液动力学和减轻术后窒息感方面具有优势.
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