异常的皮质形态模式与慢性心力衰竭患者的认知障碍有关
Yu Ting Liu1, Yu Ting Yang1, Chun Xiang Tang1
1Department of Radiology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.
The European journal of neuroscience
|May 7, 2024
概括
慢性心力衰竭患者表现出与改变的大脑结构相关的认知障碍. 这些皮质变化可能作为心力衰竭认知衰退的成像生物标志物.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 认知障碍在慢性心力衰竭 (HF) 中很常见.
- 与HF相关的认知缺陷的潜在神经解剖学机制尚未得到充分理解.
研究的目的:
- 研究慢性HF患者的大脑皮层形态和认知功能之间的关系.
- 确定认知障碍的神经解剖学预测因子和HF中主要的不良心血管事件.
主要方法:
- 追溯性研究比较49名慢性HF患者和49名健康对照 (HCs).
- 大脑结构性MRI被用来评估皮质厚度,复杂性,深度和旋转.
- 分析了认知评估和临床变量,包括用于不良事件预测的后勤回归.
主要成果:
- 与HC患者相比,HF患者的认知分数显著降低,皮质厚度,深度和关键大脑区域的化减少,与HC患者相比.
- HF持续时间和NYHA类与皮质形态负相关.
- 皮层厚度,特别是在左侧骨干部,与全球认知有积极的关联.
结论:
- 皮质形态异常与慢性HF的认知障碍有关.
- 皮层形态可能作为潜在的成像生物标志物用于高频率认知功能障碍.
- NYHA类是HF患者不良结果的独立预测因素.
相关概念视频
01:17Pathophysiology of Heart Failure
1.6K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K