压力表型框架:一种多学科的生物行为方法来评估和治疗适应不良的压力生理学
Rachel Gilgoff1, Summer Mengelkoch2, Jorina Elbers3
1Sean N. Parker Center for Allergy and Asthma Research, Stanford University, Palo Alto, CA, USA.
Stress (Amsterdam, Netherlands)
|May 7, 2024
概括
毒性压力显著影响健康,但缺乏生物标志物和向治疗. 本研究概述了一个框架,以确定压力影响,并指导精准医学以获得更好的健康结果.
科学领域:
- 压力生物学 压力生物学
- 慢性疾病 慢性疾病 慢性疾病
- 精准医学是一门精准的医学.
背景情况:
- 失调的压力生物学驱动终身健康差异.
- 目前在有毒压力生物标志物,治疗方法和临床指南方面存在差距.
- 需要标准化的方法来评估和管理与压力相关的健康问题.
研究的目的:
- 为了解决理解和治疗有毒压力的关键差距.
- 系统地描述压力失调的系统和机制.
- 介绍一个新的压力表型框架,用于精准医学在与压力相关的疾病.
主要方法:
- 对关键的压力失调系统和机制的系统描述.
- 总结指标,生物标志物和用于评估应激反应的工具.
- 突出治疗方法,以使与压力相关的功能正常化.
主要成果:
- 确定受压力影响的关键生物,行为和认知系统.
- 汇编了当前应激反应评估工具和生物标志物的汇编.
- 对减轻有毒压力影响的治疗策略的概述.
结论:
- 拟议的压力表型框架为与压力相关的疾病提供了精准医学.
- 该框架旨在指导临床实践和对有毒压力的干预评估.
- 标准化方法对于预防和治疗与压力相关的健康问题至关重要.
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