唤起反应的相似性并不意味着宏观网络状态的相似性
Javier Rasero1,2,3, Richard Betzel4, Amy Isabella Sentis2,5
1Department of Psychology, Carnegie Mellon University, Pittsburgh, PA, USA.
Network neuroscience (Cambridge, Mass.)
|May 7, 2024
概括
神经科学经常假设类似的大脑活动意味着相同的网络. 然而,这项研究表明,两项具有相似激活模式的任务使用了不同的潜在大脑网络,从而挑战了这一假设.
科学领域:
- 认知神经科学 认知神经科学
- 计算神经科学是一种神经科学.
背景情况:
- 神经科学通常假设类似的大脑激活模式表明共享的底层神经网络.
- 计算模型表明,相同的活动模式可以从不同的网络架构中产生.
研究的目的:
- 调查两个执行控制任务期间大脑区域的类似激活模式是否意味着相同的底层神经网络招募.
- 使用功能相关性,比较色词Stroop任务和多源干扰任务 (MSIT) 的网络配置文件.
主要方法:
- 在242名健康受试者中,比较了区域智能的激活模式和功能相关性概况.
- 利用基于边缘时间序列的即时功能相关性来估计与任务相关的网络.
- 分析了Stroop任务和MSIT的不一致和一致条件之间的差异.
主要成果:
- 颜色词Stroop任务和MSIT表现出明显不同的网络配置文件,尽管激活了类似的大脑区域.
- 在各种分析级别和方法管道中观察到网络配置文件的差异.
- 功能相关性配置文件显示,任务之间的差异比单独的激活模式更大.
结论:
- 这项研究驳斥了假设相同的激活模式必然表明相同的底层神经表征的假设.
- 任务表示应在节点 (区域) 和边缘 (连接) 层面独立评估.
- 在推断神经网络参与时,未来的研究应该考虑激活和连接.
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