相关实验视频

Updated: Jun 27, 2025

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

The Mesenteric Lymph Duct Cannulated Rat Model: Application to the Assessment of Intestinal Lymphatic Drug Transport

Published on: March 6, 2015

通过肠道淋巴运输提供口服药物,使用基于脂质的热体液晶

Linh Dinh¹, Bingfang Yan¹

¹Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH 45229, USA.

Liquids

|May 7, 2024

概括

利奥托普液晶 (LLC) 通过在胃肠道中保护药物,提供增强的口服药物输送. 战略重点是针对肠道淋巴运输,以提高药物的生物可用性.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
生物医学工程生物医学工程

背景情况:

热液晶 (LLCs) 在液相内具有独特的晶体结构.
有限公司可以封装疏水性,水友性和双友性剂.
它们在胃肠道中的稳定性使得它们成为口服药物输送的有希望的药物.

研究的目的:

审查LLC用于口服药物输送的优势.
探索针对肠道淋巴运输的LLC配方.
讨论通过淋巴通路增强药物生物可用性的策略.

主要方法:

分析小细胞组成,LLC结构和肠道运输之间的关系.
调查基于脂质的LLCs促进胆米克朗分泌.
设计LLC纳米颗粒与M细胞向配体.

主要成果:

LLCs保护治疗剂在胃肠道中免受降解.
特定的LLC成分和结构会影响肠道的运输和吸收.
有针对性的策略可以增强通过LLC交付的药物的淋巴运输.

结论:

有限公司是口服药物输送的多功能载体,保护各种药物.
肠道淋巴运输是提高口服药物的生物可用性的关键途径.
针对性LLC配方,包括基于脂质的系统和针对M细胞的纳米粒子,显示出显著的潜力.

关键词:

细胞M细胞M细胞基洛米龙是一种基洛米龙.立方体体的部分是立方体体.六体体体是指六体体体的组成部分.肠道淋巴运输是指肠道淋巴运输.热的液晶液晶热的液晶口服传递系统是口服传递系统.持续释放持续释放持续释放

更多相关视频

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

Published on: February 8, 2017

Using Caco-2 Cells to Study Lipid Transport by the Intestine

Using Caco-2 Cells to Study Lipid Transport by the Intestine

Published on: August 20, 2015

相关概念视频

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...

Drug Delivery: Enteral Route

Drug Delivery: Enteral Route

The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.

Routes of Drug Administration: Enteral

Routes of Drug Administration: Enteral

Medications can be administered through the enteral route using liquids, capsules, or tablets.
Enteral administration involves drug administration via the mouth in two ways: orally or sublingually.
Unlike sublingually drugs, drugs that are taken orally pass through the gastrointestinal (GI) tract and get metabolized by the liver. Once metabolized, the drug is absorbed into the systemic circulation, reaching different body parts via the bloodstream. However, while passing through the stomach,...

Drug Delivery: Miscellaneous Routes

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...

Drug Absorption: Overview

Drug Absorption: Overview

The process of drug absorption signifies the transition of a drug from its site of administration into the plasma. This process is influenced by various factors, including the route of administration, the anatomy of the absorption site, the mechanism of absorption, gut motility, and the drug's physicochemical properties.
When drugs are injected intravenously, they directly enter the systemic circulation. Alternatively, orally administered drugs navigate through the gastrointestinal (GI)...