预测质母细胞瘤复发使用多参数MRI成像在基线不增强周围瘤区域的预测
Zhen Xing1,2, Cong Wang3, Wen Yang4
1Department of Radiology, The First Affiliated Hospital, Fujian Medical University, Fuzhou, 350005, China.
Heliyon
|May 7, 2024
概括
多参数MRI可以预测在非增强区域的质母细胞瘤复发. 结合T2加权流体减弱倒置恢复,扩散加权成像和 perfusion 成像,可以有效估计未来瘤生长的风险.
科学领域:
- 神经成像是一种神经成像.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 质母细胞瘤复发通常发生在非增强周瘤区域.
- 准确预测复发对于患者管理至关重要.
研究的目的:
- 评估多参数MRI在预测非增强周瘤区域中的质母细胞瘤复发的可行性.
- 为了确定成像生物标志物,以便早期检测瘤再生.
主要方法:
- 58名质母细胞瘤患者接受了多参数MRI (T2-FLAIR,DWI,DSC PWI).
- 分析了复发和没有复发的非增强周部区域.
- 计算了明显扩散系数 (ADC) 和相对脑血量 (rCBV).
主要成果:
- 较低的相对T2-FLAIR信号,ADC和rADC,但较高的rCBV与复发相关.
- rCBV值 (≥0.89) 预测复发,敏感度为84.7%,特异性为83.6%.
- 综合的MRI参数在预测方面表现优于单独的rCBV.
结论:
- 多参数核磁共振 (MRI) 是可行的预测质母细胞瘤在非增强周瘤区域的复发.
- 结合T2-FLAIR,DWI和DSC PWI,可以有效估计未来瘤复发风险.
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