高灵敏度CRP的COVID-19与更差的动态临床参数和结果相关
Kunapa Iam-Arunthai1, Supat Chamnanchanunt1,2, Pravinwan Thungthong1
1Division of Hematology, Department of Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Bangkok, Thailand.
Frontiers in medicine
|May 7, 2024
概括
在住院COVID-19患者中高灵敏度C反应蛋白 (hsCRP) 的升高预示着严重的结果. 较高的hsCRP水平与重症监护室 (ICU) 入院,急性损伤和死亡的风险增加有关.
科学领域:
- 传染性疾病 传染性疾病
- 临床生物化学 临床生物化学
- 关键护理医学 关键护理医学
背景情况:
- COVID-19与严重的炎症有关,通常由炎症标志物升高表示.
- 高灵敏度C反应蛋白 (hsCRP) 是系统性炎症的关键生物标志物.
研究的目的:
- 研究住院COVID-19患者hsCRP水平及其临床结果之间的关联.
- 分析hsCRP在住院期间的变化轨迹及其对患者预后的影响.
主要方法:
- 研究了2021年至2023年期间入院的184名成年COVID-19患者的队列.
- 在入院和住院期间测量hsCRP水平.
- 评估了临床结果,包括重症监护室 (ICU) 的要求,急性损伤,血栓事件和死亡率.
主要成果:
- 近一半的患者 (47.3%) 在入院时呈现高hsCRP (>5.0 mg/L).
- 升高的hsCRP与更高的ICU入院率显著相关 (aOR,2.3),极高的水平显示出更大的风险 (aOR,2.65).
- 在第五天,高hsCRP水平与急性损伤 (aOR,4.13),ICU入院 (aOR,2.67) 和死亡 (aOR,4.24) 相相关,高hsCRP患者的生存率较低.
结论:
- 升高的hsCRP是住院COVID-19患者不良临床结果的重要预测因素,包括ICU入院,急性损伤和五天内死亡.
- 这些发现强调了密集监测和管理高hsCRP水平的COVID-19患者的重要性.
- 对hsCRP动态及其与病毒载荷的相关性进行进一步的研究可能会对疾病的严重程度和进展提供更深入的见解.
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