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相关概念视频

Bioreactor Design and Operational System01:29

Bioreactor Design and Operational System

200
Bioreactors are engineered vessels designed to cultivate microorganisms under controlled conditions for industrial bioprocessing. They maintain sterility and allow precise regulation of pH, temperature, oxygen, and nutrient levels to optimize microbial growth and metabolite production. Bioreactors range from small laboratory units of 1 liter to industrial systems holding up to 500,000 liters, though only about 75% of their volume is actively used for fermentation. The remaining headspace...
200

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Engineering Biological-Based Vascular Grafts Using a Pulsatile Bioreactor
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软生物反应器系统:向工程化MSK软组织迈出的必要一步?

Nicole Dvorak1, Zekun Liu1, Pierre-Alexis Mouthuy1

  • 1Botnar Institute of Musculoskeletal Sciences, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.

Frontiers in robotics and AI
|May 7, 2024
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概括

软生物反应器为肌肉骨组织的组织工程 (TE) 提供先进的解决方案. 这些系统应用了复杂的,生理上相关的多轴应力,克服了传统刚性生物反应器的局限性,以改善移植的发展.

关键词:
生物反应器的生物反应器机械刺激是一种机械刺激.机械传导 机械传导肌肉骨组织组织.软机器人软机器人 软机器人软传感器 软传感器软系统软系统是软系统.组织工程是组织工程.

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科学领域:

  • 组织工程是组织工程.
  • 生物反应器技术技术
  • 肌肉骨组织 (MSK) 组织再生

背景情况:

  • 组织工程 (TE) 旨在使用受控环境 (生物反应器) 为受损组织创建功能移植.
  • 机械应力对肌肉骨 (MSK) 组织通过机械传导的生长和成熟至关重要.
  • 目前的生物反应器经常使用过于简单的机械应力,阻碍了工程MSK移植的临床翻译.

研究的目的:

  • 审查传统的刚性生物反应器及其在应用生理学相关的机械应力方面的局限性.
  • 要突出MSK TE软生物反应器的进步,使复杂的多轴加载成为可能.
  • 讨论软生物反应器在开发功能软组织工程移植的潜力.

主要方法:

  • 对MSK TE.软体生物反应器系统的现有文献的审查.
  • 检查结合软部件 (室内,执行器,传感器) 的生物反应器设计.
  • 对应用复杂负载条件对组织结构的研究进行分析.

主要成果:

  • 传统的刚性生物反应器通常仅限于单轴负荷,无法模拟体内条件.
  • 软生物反应器利用灵活的组件来施加多轴应力,并使现场测量成为可能.
  • 软生物反应器所应用的复杂加载条件显示出改善组织成熟的前景.

结论:

  • 软生物反应器代表了MSK TE.对硬系统的显著进步.
  • 这些平台可以更好地复制体内机械环境,促进功能性组织发育.
  • 软生物反应器具有相当大的潜力,可以加速工程MSK移植的临床应用.