相关实验视频

Updated: Jun 27, 2025

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Therapeutic Evaluation of Fecal Microbiota Transplantation in an Interleukin 10-Deficient Mouse Model

Published on: April 6, 2022

炎症性细胞因子可以调解肠道微生物群和男性不孕症之间的因果关系:双向,调解,多变量孟德尔随机化研究

Haoxi Zou¹, Ningning Xu¹, Huanying Xu^1,2

¹Foshan Clinical Medical School of Guangzhou University of Chinese Medicine, Foshan, China.

Frontiers in endocrinology

|May 7, 2024

概括

特定的肠道细菌和炎症性细胞因子与男性不孕症 (MI) 有因果关系. 肝细胞生长因子 (HGF) 调解了Bacteroides对心脏病风险的保护作用.

科学领域:

遗传学是一个遗传学.
微生物学微生物学
免疫学免疫学免疫学

背景情况:

肠道微生物群与男性不孕症 (MI) 的关联已知,但因果关系和调解者需要进一步调查.
像门德尔随机化 (MR) 这样的遗传方法可以阐明暴露和结果之间的因果关系.

研究的目的:

调查肠道微生物组组成和男性不孕不育之间的因果关系.
探索炎症性细胞因子在肠道微生物组-MI轴中的潜在调解作用.
用双向门德尔随机化方法进行强大的遗传分析.

主要方法:

采用双向,介导和多变量门德尔随机化 (MR) 分析.
利用大规模的全基因组关联研究 (GWAS) 数据对肠道微生物 (n=18,340),炎症性细胞因子 (n=13,365) 和男性不孕症 (n=120,706) 的数据.
逆方差加权 (IVW) 是主要的分析方法,并补充了其他MR技术.

主要成果:

确定了Anaerotruncus和心脏病发作风险增加 (OR=1.81) 之间的因果关系.
发现细菌菌体因果关系与心脏病发作风险降低相关 (OR=0.57).
肝细胞生长因子 (HGF) 与心脏病发作风险降低有关 (OR=0.50),而单细胞化疗蛋白-3 (MCP-3) 与风险增加有关 (OR=1.28).
经介导的MR分析显示,HGF介导了Bacteroides对MI的因果作用的38.9%.

结论:

建立了特定肠道微生物,炎症性细胞因子和男性不孕症之间的因果关系的遗传基础.
肝细胞生长因子 (HGF) 成为Bacteroides影响男性不孕症的关键途径中的关键调解者.

关键词:

门德尔的随机化有关因果推理的推理.遗传学遗传学遗传学是一个肠道微生物肠道微生物这是一种炎症性细胞因子.男人的不孕不育症.

更多相关视频

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

Published on: December 16, 2021

Transurethral Instillation Procedure in Adult Male Mouse

Transurethral Instillation Procedure in Adult Male Mouse

Published on: November 2, 2017

相关概念视频

Infertility in Males

Infertility in Males

Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Spermatogenesis

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...