在患有格雷夫斯病的患者中,超重作为同时发生甲状腺癌的生物标志物
Joonseon Park1, Solji An1, Ja Seong Bae1
1Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Frontiers in endocrinology
|May 7, 2024
概括
患有格雷夫斯病的超重患者有较高的同时发生甲状腺癌的风险. 下腺体重和甲状腺刺激激素受体抗体水平也是格雷夫斯病患者恶性瘤的指标.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 甲状腺学 甲状腺学
背景情况:
- 格雷夫斯病复杂化了甲状腺结节的诊断和管理.
- 在Graves病中确定甲状腺癌的生物标志物对于手术规划至关重要.
- 大多数格雷夫斯病患者接受非手术治疗.
研究的目的:
- 在Graves病患者中识别并发甲状腺癌的生物标志物.
- 为了评估超重状态对甲状腺癌风险的影响,格雷夫斯病.
主要方法:
- 对122名接受甲状腺手术的格雷夫斯病患者进行了回顾性队列研究.
- 分析身体质量指数 (BMI),甲状腺功能测试和甲状腺刺激激素受体抗体 (TR-Ab).
- 超重量定义为BMI≥25kg/m2. 超重量定义为BMI≥25kg/m2. 超重量定义为BMI≥25kg/m2.
主要成果:
- 超重患者 (BMI ≥25 kg/m2) 的恶性瘤风险显著增加 (OR,3.108;p=0.021).
- 较低的甲状腺体重和较低的手术前TR-Ab水平被确定为恶性瘤的生物标志物.
- 88.5%的患者接受了完全或近乎完全的甲状腺切除术.
结论:
- 超重状态是Graves病同时出现甲状腺癌的独立风险因素.
- 下腺体重和TR-Ab水平是这种人群中甲状腺癌的潜在生物标志物.
- 包括BMI在内的全面评估对于超重的格雷夫斯病患者来说至关重要,以检测并发的甲状腺癌.
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